JiAyir Brown

49ers offensive lineman Spencer Burford officially has been ruled out of San Francisco’s Week 17 game against the Detroit Lions on Monday night at Levi’s Stadium.

San Francisco 49ers coach Kyle Shanahan speaks with media following practice Saturday afternoon at Levis Stadium.

San Francisco 49ers guard Spencer Burford did not participate in practice Thursday, but Kyle Shanahan is hopeful he will be healthy enough to suit up Monday.

San Francisco coach Kyle Shanahan speaks with the media on his weekly conference call after the 49ers’ loss to the Miami Dolphins on Sunday.

The San Francisco 49ers avoided significant injuries in their 12-6 loss to the Los Angeles Rams on Thursday at Levi’s Stadium.

Head coach Kyle Shanahan speaks to Bay Area reporters Friday after San Francisco’s Week 15 loss to the Los Angeles Rams.

Matt Maiocco lists five 49ers players who must step up in San Francisco’s must-win game against the Los Angeles Rams on Thursday night at Levi’s Stadium.

On “49ers Talk,” co-hosts Matt Maiocco and Jennifer Lee Chan discuss San Francisco wide receiver Deebo Samuel’s drop in production during the 2024 NFL season.

San Francisco 49ers coach Kyle Shanahan explained why Ji’Ayir Brown didn’t start alongside Talanoa Hufanga against the Chicago Bears on Sunday.

49ers coach Kyle Shanahan speaks to Bay Area reporters Monday after San Francisco’s Week 14 win over the Chicago Bears.

Matt Maiocco lists five 49ers to keep an eye on in San Francisco’s must-win game against the Chicago Bears on Sunday at Levi’s Stadium.

Matt Maiocco and Jennifer Lee Chan discuss rookie Isaac Guerendo’s big opportunity to fill the San Francisco’s starting running back role for the 49ers in their week 14 matchup vs. the Bears Sunday at Levi’s Stadium.

Safety Ji’Ayir Brown speaks with reporters after the San Francisco 49ers’ win over the Tampa Bay Buccaneers on Sunday at Raymond James Stadium.

Matt Maiocco lists five 49ers to keep an eye on in San Francisco’s Week 5 NFC West clash against the Arizona Cardinals on Sunday at Levi’s Stadium.

On “49ers Talk,” Matt Maiocco and Greg Papa break down the unique challenge San Francisco will face Sunday in slowing down Kyler Murray and the Arizona Cardinals.

The 49ers’ secondary very much appreciated the pressure applied by San Francisco’s defensive line against the New England Patriots on Sunday.

49ers safety Ji’Ayir Brown speaks to reporters ahead of San Francisco’s matchup against the Los Angeles Rams on Sunday to discuss the challenge of facing veteran QB Matthew Stafford.

NFL back judge Tyree Walton, viral for the speed showcased on Justin Jefferson’s 97-yard touchdown against the 49ers, was a college running back.

’49ers Talk’ co-hosts Matt Maiocco and Jennifer Lee Chan discuss San Francisco 49ers receiver Brandon Aiyuk and his performance against the Minnesota Vikings.

Fred Warner and the San Francisco 49ers couldn’t get the defense stops they needed during their rough 23-17 loss to the Minnesota Vikings on Sunday.