Brandon Aiyuk

49ers inactives: Brandon Aiyuk, Ambry Thomas out vs. Giants

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The 49ers won't have Brandon Aiyuk, one of their biggest weapons, when they face the New York Giants on Thursday night at Levi's Stadium.

Aiyuk began the day questionable because of a left shoulder injury, and 90 minutes before kickoff, the 49ers officially ruled him out.

The 49ers elevated wide receiver Chris Conley from the practice squad earlier in the day in the event Aiyuk wasn't able to go.

Additionally, cornerback Ambry Thomas is inactive, with defensive back Tre Swilling promoted to the active roster.

Here are the 49ers inactives for the Thursday Night Football game.

As for the Giants, they will be without star running back Saquon Barkley, who sustained an ankle injury Sunday against the Arizona Cardinals.

The 49ers are looking to improve to 3-0 this season and they'll have to do it without Aiyuk, one of quarterback Brock Purdy's favorite targets.

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