The 49ers might be facing off against a New York Giants team without its best player on "Thursday Night Football" at Levi's Stadium.
Giants running back Saquon Barkley left New York's 31-28 win over the Arizona Cardinals on Sunday at State Farm Stadium late in the fourth quarter with an apparent ankle injury.
ESPN's Adam Schefter reported, citing a source, that the Giants' initial belief is Barkley did not suffer a high-ankle sprain, but rather an "ordinary sprain."
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Prior to the injury, Barkley had 17 carries for 63 rushing yards and a touchdown on the ground Sunday to go along with six receptions for 29 receiving yards and a touchdown through the air. He played a big role in New York erasing an early 20-0 deficit to the Cardinals.
After undergoing an MRI on Monday, Barkley will have just three days of rest before the Giants face off against the 49ers, which certainly puts his availability for the Week 3 matchup in doubt.
The 49ers should be the favorites at home, but if Barkley is unavailable, San Francisco could have a significant edge over the Giants.