The Latest
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How Greenlaw, Hufanga are impacting 49ers with returns imminent
The San Francisco 49ers need a spark, and two returning defense stars might be able to provide that boost.
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How Guerendo has prepared for opportunity as 49ers' lead back
Rookie 49ers running back Isaac Guerendo will get his shot in San Francisco’s Week 14 game against the Chicago Bears.
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Shanahan ‘very satisfied' with Sorensen amid 49ers defense struggles
Kyle Shanahan shouldered the blame for the San Francisco 49ers’ defensive and overall team struggles this season.
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How 49ers are supporting Williams, Ward through unthinkable tragedies
Kyle Shanahan and the San Francisco 49ers are rallying around Trent Williams and Charvarius Ward after the NFL stars both lost children this season.
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49ers to open Hufanga's practice window; Givens headed to IR
The injury bug has bitten the San Francisco 49ers again entering Week 14, with multiple players headed to injured reserve.
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Where 49ers can turn with top two running backs headed to IR
Jennifer Lee Chan highlights potential external options the San Francisco 49ers could consider after injuries to Christian McCaffrey and Jordan Mason.
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How PFF graded Purdy, 49ers in demoralizing Week 13 loss to Bills
The 49ers’ PFF grades reflect the lopsided score from San Francisco’s loss to the Buffalo Bills on Sunday.
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Juice disappointed he fumbled rare rushing opportunity in 49ers' loss
Kyle Juszczyk lamented his momentum-killing fumble in the San Francisco 49ers’ loss to the Buffalo Bills on Sunday.
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49ers vs. Bills as it happened: Reaction, analysis of SF's 35-10 loss
Here’s everything you need to know from the San Francisco 49ers’ 35-10 loss to the Buffalo Bills on Sunday at Highmark Stadium, with highlights, postgame reaction and analysis.
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How Mustapha's path to 49ers was influenced by Cowboys fan mom
San Francisco 49ers rookie Malik Mustapha sat down with NBC Sports Bay Area’s Jennifer Lee Chan to discuss how he decided to play defense and the thrill of being drafted by his favorite childhood team.