September 7, 2022 10:26 am San Francisco 49ers' biggest storylines this season NFL football is right around the corner. Here are the 3 biggest storylines for the San Francisco 49ers entering 2022. 49ers videos 1:02 Smith reacts to being called toughest opponent Staley, Williams faced 2:01 Aldon Smith reflects on NFL career, lessons learned 2:51 Former 49er Aldon Smith shares message to youth on mental health 0:58 49ers Talk: 49ers sign Terrell Owen's son Terique as undrafted free agent 1:25 49ers Talk: Is ‘writing on the wall' for Samuel's future in San Francisco?