October 12, 2021 4:06 pm Biggest games to watch in Week 6 of the NFL season It’s the first bye week of the season, plus two more teams head over to London for Week 6 of NFL action. 49ers videos 1:02 Smith reacts to being called toughest opponent Staley, Williams faced 2:01 Aldon Smith reflects on NFL career, lessons learned 2:51 Former 49er Aldon Smith shares message to youth on mental health 0:58 49ers Talk: 49ers sign Terrell Owens' son Terique as undrafted free agent 1:25 49ers Talk: Is ‘writing on the wall' for Samuel's future in San Francisco?