October 7, 2021 7:23 pm 49ers' Bosa preparing for ‘challenge' vs. Cardinals' Murray Heading into Week 5, Nick Bosa and the 49ers defense gear up to face the first place Arizona Cardinals and their quarterback Kyler Murray, who continues to put up big numbers. 49ers videos 1:02 Smith reacts to being called toughest opponent Staley, Williams faced 2:01 Aldon Smith reflects on NFL career, lessons learned 2:51 Former 49er Aldon Smith shares message to youth on mental health 0:58 49ers Talk: 49ers sign Terrell Owen's son Terique as undrafted free agent 1:25 49ers Talk: Is ‘writing on the wall' for Samuel's future in San Francisco?
