49ers vs. Rams betting odds: Week 18 moneyline, spread

It all comes down to Week 18 for the 49ers.

Their ticket to the postseason might be punched before they take the field on Sunday if the Atlanta Falcons manage to defeat the New Orleans Saints. If the Saints win (New Orleans opens as 4.5-point favorites), the 49ers will have to beat the favored Los Angeles Rams on the road in order to secure a playoff spot.

The 12-4 Rams will be looking to capture an NFC West division title, and they’ll likely need a win to do so with the 11-5 Arizona Cardinals hosting the 6-10 Seattle Seahawks.

That could put pressure on the 49ers, who will have either a veteran quarterback playing with an injured thumb or a rookie quarterback playing in a playoff-like atmosphere. Trey Lance started in place of the injured Jimmy Garoppolo on Sunday, earning his first career victory as a starter in the 49ers’ 23-7 win over the Houston Texans. But Kyle Shanahan said after the game that Garoppolo remains the team’s starting quarterback and will return to the lineup in the regular-season finale if he is healthy enough to play.  

Here is all the betting info to know before 49ers-Rams:

49ers vs. Rams Moneyline, Spread and Total

Line: Rams -3.5

Over/under: 44.5

49ers team total O/U: 20.5

Rams team total O/U: 24.5

Moneyline: 49ers +160 | Rams -191

History is on the 49ers’ side, even if the spread isn’t. San Francisco has won its last five matchups against the Rams, dating back to 2019. 

When the two teams met earlier this season, the 49ers cruised to a 31-10 victory. Jimmy Garoppolo completed 15 of 19 passes for 182 yards and two touchdowns in the win. Elijah Mitchell added 91 yards on the ground. 

For more, here are the full odds for the upcoming 49ers-Rams game.

All odds are provided by our partner, PointsBet.

49ers Props to Watch for Week 18

Elijah Mitchell rushing/receiving yards: 90

Deebo Samuel receiving yards: 55.5

49ers ATS Record and Game Results

The 49ers were heavy favorites against the Texans at -14 and they managed to cover with a 23-7 win, bringing them to 8-8 against the spread this season.

Here are some notable storylines following that loss in Tennessee:

• Lance vs. Jimmy G passing chart says it all for the 49ers
• What we learned about Lance in 49ers’ crucial win over Texans
• Shanahan says Jimmy G is still 49ers’ starting quarterback if healthy

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49ers Futures Odds Before Week 18

The 49ers’ Super Bowl odds improved slightly following their Week 17 win over the Texans:

49ers to make playoffs -165

49ers to win NFC +1600

49ers to win Super Bowl +3500

Here are some of the odds for various 49ers players to win season-long awards:

Nick Bosa to win Defensive Player of the Year +10000

The full docket of NFL futures can be found at PointsBet here.

Editor's note: All odds are provided by our partner, PointsBet. PointsBet is our Official Sports Betting Partner and we may receive compensation if you place a bet on PointsBet for the first time after clicking our links.