Marquise Goodwin played all 16 games for the 49ers last season in his breakout year full of career highs across the board.
Last season also marked the first time Goodwin didn't miss a single game in his now-six-year NFL career.
This season, the injury bug is back.
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SIGN UP HERE Goodwin will miss the 49ers' game Sunday against the Cardinals with hamstring and quadriceps injuries, according to ESPN's Adam Schefter. Goodwin now has missed two games this season, and he also left the season opener early.
Goodwin has just five catches for 54 yards and one touchdown in three games played this season.