OAKLAND -- Darren McFadden re-injured his sprained right ankle late in the Raiders' 26-13 loss to Denver Thursday night.
The oft-injured running back did not finish the game.
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McFadden, who has never played more than 13 games in an NFL season, missed the previous four games with the high ankle sprain he suffered against Tampa Bay on Nov. 4. This after missing the last nine games of the 2011 season with a Lisfranc sprain of his right foot.
Against the Broncos on prime time, McFadden dropped the first ball he touched, a pass across the middle from Carson Palmer and was essentially a non-factor for the game, rushing for 52 yards on 11 carries, though one rush was for 36 yards in the third quarter.
McFadden did, though, have a six-yard catch-and-run touchdown to culminate that same drive on a beautifully-executed pump-fake and screen to the left.
For the season, McFadden is averaging a career-low 5.4 yards per carry, rushing for 507 yards on 150 attempts.
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"Coming off a short week, it's hard," McFadden said. "I feel like we prepared well and we went out there and we tried to execute, but we just came out on the short end."
Cornerback Michael Huff also did not finish the game, due to an injury to his right wrist. Safeties Mike Mitchell (neck), Tyvon Branch (left ankle) and Matt Giordano (undisclosed) all left the game at one time, only to return and finish.
"We just got off the field so I don't really know exactly where it is," coach Dennis Allen said of McFadden's injury. "I just know he wasn't able to finish the game. (I'm more) concerned…with the injuries in the secondary."