The 49ers (1-2) are without Jimmy Garoppolo and on the road Sunday against the Chargers (1-2) at StubHub Center.
Will C.J. Beathard be able to step in and lead the 49ers to victory? How much will they miss Garoppolo? Can the San Francisco defense slow down L.A. stalwarts Philip Rivers and Melvin Gordon?
We'll find out the answers to those questions and more soon enough.
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Here's how and when to watch the 49ers-Chargers game, both on TV and online. You also can follow our live blog of the game.
Start time: Sunday, Sept. 30, at 1:25 a.m. PT
TV channel: CBS
Live stream: fuboTV -- Get a free trial
This Sunday, be sure to watch 49ers Pregame Live at noon and 49ers Postgame Live immediately after the game on NBC Sports Bay Area and live streaming on the NBC Sports app. Greg Papa, Donte Whitner, Jeff Garcia, Matt Maiocco and Laura Britt will have everything you need to know.