D.J. Jones' season is over.
49ers coach Kyle Shanahan said on KNBR Thursday that Jones will go on season-ending injured reserve, ending his breakout season.
Stay in the game with the latest updates on your beloved Bay Area and California sports teams! Sign up here for our All Access Daily newsletter.
Jones has started all 11 games in which he appeared this season. He has recorded 23 tackles and two sacks.
Shanahan said Wednesday that the 49ers were fearing Jones was lost to the season after suffering a "significant" ankle injury in the 49ers' 48-46 win over the Saints last Sunday. It appears their worst fears came true.
Solomon Thomas or Sheldon Day likely will start at nose tackle in Jones' place.
Additionally, Kentavius Street, who began practicing with the club last week, is expected to take Jones' place on the 53-man roster. Street was the 49ers' fourth-round pick in 2018 from North Carolina State but missed his entire rookie season with an ACL injury.
San Francisco 49ers
Find the latest San Francisco 49ers news, highlights, analysis and more with NBC Sports Bay Area and California.
"It feels great," Street said Wednesday. "Just knocking some rust off, just making sure my tools are as sharp as they can be. But besides that, I feel great.
"Oh, yeah. I could run through a wall right now.”
[RELATED: How Jimmy G can enter NFL record books vs. Falcons]
Jones adds to the 49ers' laundry list of injury woes on defense, joining Kwon Alexander on IR and Dee Ford, Richard Sherman and Jaquiski Tartt on the shelf.